Diffusely invasive tumors occurred in the stomach of a 9-year-old fema
le cougar (Felis concolor) from a zoo in Japan. The tumors consisted o
f tubular adenocarcinoma cells, and had infiltrative growth to the sub
mucosa and muscularis propria. Tumor cells were positive for carcinoem
bryonic antigen (CEA), lysozyme, epithelial membrane antigen (EMA), ga
strin, alpha-1-fetoprotein (AFP), keratin, and B72.3. Mucin-like mater
ials occurred within cytoplasmic vacuoles.