EFFECTIVENESS AND ACCEPTANCE OF A TROSPIU M CHLORIDE TREATMENT FOR PATIENTS WITH URGE INCONTINENCE

Study objective: Assessment of the therapeutic efficacy, tolerability and acceptance of trospium chloride in the treatment of outpatients su ffering from urge incontinence. Study design: Prospective PMS study un der section 67 section 6 AMG, performed by 645 physicians on 3,166 pat ients under routine conditions; observation period planned: 28 days; m inimum treatment period: 10 days; dosage recommendation registered is 3 x 1 tablet/day (each containing 15 mg). Patients: Data from 2,647 pa tients (1,950 women, 694 men; mean age 63 years) were suitable for sta tistical analysis. Main results: Obvious improvement in severity of ur ge symptomatology in 87.3% of all patients; reduction of daily micturi tion frequency by 39.7%; urinary incontinence was obviously decreased in that the number of patients showing urinary continence at the end o f the study was considerably increased under medication with trospium chloride. Therapeutic efficacy of the drug was assessed as being good or very good by 87% of physicains and 84.8% of patients; tolerability was considered good or very good in 97.8% and 95.8% repectively. A tot al of 28 instances of suspected adverse effects was reported. Conclusi on: Good efficacy of trospium chloride in the treatment of patients wi th urge incontinence, good tolerability, low rate of adverse effects, high acceptance.