ACUTE EFFECTS OF TTFCA ON CAPILLARY FILTRATION IN SEVERE VENOUS HYPERTENSION

The acute variation in capillary filtration [CF] was evaluated with st rain-gauge plethysmography in patients with severe venous hypertension due to deep venous disease. Two groups were selected and randomly tre ated with a single oral dose or TTFCA (60 mg or 120 mg). CF was assess ed again after 5 and 10 hours. Eleven patients were randomised in the 60 mg group and 9 in the 120 mg group. Also 5 normal subjects were stu died with the same procedure to act as controls. No variations in CF w ere observed in normal limbs. In both groups of patients there was a s ignificant decrease in CF after 5 and 10 hours. The percent decrease i n CF after 10 hours was higher in the high dose group. These results i ndicate that TTFCA is acutely effective in reducing CF and oedema in s ubjects with venous hypertensive microangiopathy. The effects of TTFCA on CF appear to be dose related.