OF MULTIPLE DOSES OF VOLATILE ANESTHETICS ON HEME ENZYMES

1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose level s was studied. 2. Liver and kidney delta-Aminolevulinic acid synthetas e (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in a nimals receiving one dose of Isoflurane. 3. Blood Porphobilinogenase a nd deaminase (50%, P < 0.01) inhibition was produced only when animals received a single dose of the anesthetics. 5. ALA-S induction observe d after the third dose of anesthetics could be a consequence of long l asting depletion in heme synthesis produced by blocking at uroporphyri nogen level.