EFFECT OF THE SULFONYLUREA GLYBURIDE ON GLYCOGEN-SYNTHASE ACTIVITY INALLOXAN-INDUCED DIABETIC RAT ADIPOCYTES

Authors
ALTAN N ATALAY T ONGUN CO
Citation
N. Altan et al., EFFECT OF THE SULFONYLUREA GLYBURIDE ON GLYCOGEN-SYNTHASE ACTIVITY INALLOXAN-INDUCED DIABETIC RAT ADIPOCYTES, General pharmacology, 25(6), 1994, pp. 1245-1247
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
25
Issue
6
Year of publication
1994
Pages
1245 - 1247
Database
ISI
SICI code
0306-3623(1994)25:6<1245:EOTSGO>2.0.ZU;2-5
Abstract
1. The effect of glyburide (glibenclamide) treatment in vivo on the ad ipose tissue glycogen synthase activity of type II diabetic rats has b een studied. 2. Three week treatment of diabetic animals with glyburid e (5 mg/kg orally, in saline) increased adipose glycogen synthase acti vity and decreased blood glucose levels. 3. These results demonstrate that the sulfonylurea glyburide is capable of exerting direct insulin- like effect on adipose glycogen-synthase activity of type II diabetic rats in vivo.