EFFECTS OF CARBARYL ON SOME DOPAMINERGIC BEHAVIORS IN RATS

1. The effects of acute oral administration of carbaryl (10-80 mg/kg), a carbamate insecticide, on some experimental models for detecting do paminergic activity were examined in rats. Also, serum biochemical Var iables following carbaryl treatments were determined. 2. Carbaryl (20 and 40 mg/kg) significantly increased the number of apomorphine-induce d yawns and at dose of 80 mg/kg it prolonged the duration time of halo peridol-induced catalepsy. Pretreatment with carbaryl failed to affect apomorphine-induced stereotypes. 3. Carbaryl significantly reduced bl ood cholinesterase activity and elevated blood glucose levels and SGOT and SGPT activities. 4. These results indicate that low oral doses of carbaryl can cause behavioral and toxicological effects in rats.