Background: While the majority of fistulas-in-ano are anatomically sim
ple and easy to treat, a significant number are high or anatomically c
omplex and have the potential to become a major management problem. Me
thods: One hundred anti seven consecutive patients undergoing surgery
for fistula-in-ano were studied prospectively with standardized anatom
ic diagrams. Results: Fistulas were classified as superficial (15%). i
ntersphincteric (43%), trans-sphincteric (35%) or 'high' (7%). Within
each group fistulas were considered either simple or complex (high tra
cks, extra tracks or other complications), Trans-sphincteric fistulas
were more often complex than intersphincteric Fistulas (32 vs 6%). A p
rior history of perianal sepsis and surgery: was more frequent among t
he trans-sphincteric and 'high' groups. An external fistula opening wi
thin a narrow are 30 degrees either side or the posterior midline was
almost always associated with a simple superficial ol intersphincteric
fistula (97%). Anterior and especially posterolaterally located exter
nal openings were frequently associated with complex fistulas (16 and
47%, respectively) and often had trans-sphincteric or 'high' tracks (5
8 and 56%). Goodsall's Law was more accurate for posterior (91%) and i
ntersphincteric (93%) fistulas than for anterior (69%) and transsphinc
teric (68%) fistulas. Histopathology of fistula material showed unrema
rkable fistula-in-ano in 87% of requests. Six patients hall unexpected
abnormal results, including three new diagnoses of Crohn's disease. C
onclusions: The presence of additional anatomic complexity should alwa
ys bz anticipated in trans-sphincteric fistulas. Transsphincteric and
'high' fistulas are more likely to occur in females, and in patients w
ith previous perianal sepsis or surgery for fistula. External openings
close to the posterior midline almost always underlie simple fistulas
, whereas posterolateral external openings are predictive of complex f
istulas.