P. Dogan et al., OXIDATIVE-ENZYMES OF POLYMORPHONUCLEAR LEUKOCYTES AND PLASMA-FIBRINOGEN, CERULOPLASMIN, AND COPPER LEVELS IN BEHCETS-DISEASE, Clinical biochemistry, 27(5), 1994, pp. 413-418
This study was performed to investigate the antioxidant mechanisms of
polymorphonuclear leucocytes (PMN) in active stage of Behcet's Disease
. PMN activities of myeloperoxidase (p < 0.02), superoxide dismutase (
p < 0.001), catalase (p < 0.005), and glutathione peroxidase (p < 0.00
5) were significantly lower in the patients: the NADPH oxidase activit
y was significantly higher (p < 0.001) than those in controls. The pla
sma levels of ceruloplasmin (Cp), fibrinogen, and copper (Cu) were als
o significantly higher in the patients group (p < 0.001). Significant
and positive correlations were found between the glutathione peroxidas
e and catalase activities (p < 0.001) and also between the plasma Cp a
nd Cu levels (p < 0.001) in the patients group. However, no correlatio
n was observed among the other enzyme activities. In the control group
, a significantly positive correlation was present only between the pl
asma ceruloplasmin and Cu levels (p < 0.001). It was concluded that (i
mpaired PMN functions) decreased enzyme activities in the antioxidant
system and increased levels of oxygen free radicals may play a role in
tissue damage in Behcet's disease.