MEASLES VACCINATION OF THAI INFANTS BY INTRANASAL AND SUBCUTANEOUS ROUTES - POSSIBLE INTERFERENCE FROM RESPIRATORY-INFECTIONS

Reactogenicity and seroresponses were studied after standard doses of Edmonston-Zagreb measles vaccine were given intranasally (in.) and sub cutaneously (s.c.) to 6-month-old Thai children, Few children given i. n. vaccine (2/31), but most (13/21) given s.c. vaccine, seroconverted. All but 1 of 51 children were seropositive after receiving vaccine s. c. at 9 months-of-age. Upper respiratory infection (URI) outbreaks wit h onsets in the week following vaccination occurred after each vaccina tion session and were equally common in all groups URIs following i.n. vaccination at 6 months may have adversely affected response to i.n. vaccine, while URIs after s.c. vaccination at 9 months adversely affec ted final geometric mean antibody titers. I.n. measles vaccination doe s not appear to be an acceptable route for routine vaccination. (C) 19 97 Elsevier Science Ltd.