UBP5 ENCODES A PUTATIVE YEAST UBIQUITIN-SPECIFIC PROTEASE THAT IS RELATED TO THE HUMAN TRE-2 ONCOGENE PRODUCT

A gene from chromosome V of the yeast Saccharomyces cerevisiae has bee n cloned and sequenced. The deduced amino acid sequence encoded by thi s gene is similar to several ubiquitin-specific proteases from yeast, especially at the highly conserved domain. It is thus named UBP5. UBP5 is also closely related to the human Tre-2 and the mouse Unp oncogene products. This study adds a new member to the ubiquitin protease fami ly and suggests that alteration of ubiquitin protease activity may res ult in cancer in mammals. However, disruption of the UBP5 gene in a ha ploid strain did not result in a noticeable phenotypic alteration. The sequence has been deposited in the GenBank data library under Accessi on Number U10082.