W. Xiao et al., UBP5 ENCODES A PUTATIVE YEAST UBIQUITIN-SPECIFIC PROTEASE THAT IS RELATED TO THE HUMAN TRE-2 ONCOGENE PRODUCT, Yeast, 10(11), 1994, pp. 1497-1502
A gene from chromosome V of the yeast Saccharomyces cerevisiae has bee
n cloned and sequenced. The deduced amino acid sequence encoded by thi
s gene is similar to several ubiquitin-specific proteases from yeast,
especially at the highly conserved domain. It is thus named UBP5. UBP5
is also closely related to the human Tre-2 and the mouse Unp oncogene
products. This study adds a new member to the ubiquitin protease fami
ly and suggests that alteration of ubiquitin protease activity may res
ult in cancer in mammals. However, disruption of the UBP5 gene in a ha
ploid strain did not result in a noticeable phenotypic alteration. The
sequence has been deposited in the GenBank data library under Accessi
on Number U10082.