A 12-5-KB FRAGMENT OF THE YEAST CHROMOSOME-II CONTAINS 2 ADJACENT GENES ENCODING RIBOSOMAL-PROTEINS AND 6 PUTATIVE NEW GENES, ONE OF WHICH ENCODES A PUTATIVE TRANSCRIPTIONAL FACTOR

The nucleotide sequence of a 12.5 kb fragment localized to the right a rm of chromosome II of Saccharomyces cerevisiae has been determined. T he sequence contains eight putative genes. Two of them are contiguous and represent two ribosomal protein genes: SUP46 and URP1. SUP46 is im plicated in translation fidelity and encodes the ribosomal protein S13 . URP1 is homologous to the rat ribosomal protein gene L21. The open r eading frame (ORF) YBR1245 is similar in its N-terminal part to transc ription factors like SRF and MCM1. The ORF YBR1308 shows homology with proteins of the AAA-family (ATPases Associated with diverse cellular Activities). Two genes are predicted to encode putative membrane prote ins. The sequence has been deposited in the EMBL data library under Ac cession Number U02073.