SUPPRESSIVE EFFECTS OF EUGENOL AND GINGER OIL ON ARTHRITIC RATS

This study examined the effect of eugenol and ginger oil on severe chr onic adjuvant arthritis in rats. Severe arthritis was induced in the r ight knee and right paw of male Sprague-Dawley rats by injecting 0.05 mi of a fine suspension of dead Mycobacterium tuberculosis bacilli in liquid paraffin (5 mg/ml). Eugenol(33 mg/kg) and ginger oil(33 mg/kg), given orally for 26 days, caused a significant suppression of both pa w and joint swelling. These findings suggest that eugenol and ginger o il have potent antiinflammatory and/or antirheumatic properties.