Amphidiploid wheat hybrids are alloplasmic plants in which intergenomi
c and nuclear-cytoplasmic interactions take place simultaneously. Part
ial instability of hybrids, underlain by lack of equilibrium between g
enomes (intergenomic disbalance), has been studied in sufficient detai
l. However, current understanding of the role of nuclear-cytoplasmic d
isbalance in hybrid stability is fragmentary and inconsistent. The rev
iew focuses on nuclear-cytoplasmic interactions in distant hybrids of
cereals, with emphasis on the role of nuclear-cytoplasmic disbalance i
n the instability of wheat-rye recombinants.