SYNTHETIC FKBP12 LIGANDS - DESIGN AND SYNTHESIS OF PYRANOSE REPLACEMENTS

Authors
BIRKENSHAW TN CAFFREY MV CLADINGBOEL DE COOPER ME DONALD DK FURBER M HARDERN DN HARRISON RP MARRIOTT DP PERRY MWD STOCKS MJ TEAGUE SJ WITHNALL WJ
Citation
Tn. Birkenshaw et al., SYNTHETIC FKBP12 LIGANDS - DESIGN AND SYNTHESIS OF PYRANOSE REPLACEMENTS, Bioorganic & medicinal chemistry letters, 4(21), 1994, pp. 2501-2506
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
21
Year of publication
1994
Pages
2501 - 2506
Database
ISI
SICI code
0960-894X(1994)4:21<2501:SFL-DA>2.0.ZU;2-Z
Abstract
A number of FKBP12 ligands were designed and synthesised and their aff inity for FKBP12 assessed. In these ligands the pyranose ring of FK506 was replaced by other mole synthetically accessible groups. The prepa ration of suitable intermediates for the synthesis of ''dual domain'' inhibitors (compounds 6a-c, 15 and 22) is also described.