PHYSICOCHEMICAL ANALYSIS OF THE FACTORS GOVERNING DISTRIBUTION OF SOLUTES BETWEEN BLOOD AND BRAIN

Authors
CHADHA HS ABRAHAM MH MITCHELL RC
Citation
Hs. Chadha et al., PHYSICOCHEMICAL ANALYSIS OF THE FACTORS GOVERNING DISTRIBUTION OF SOLUTES BETWEEN BLOOD AND BRAIN, Bioorganic & medicinal chemistry letters, 4(21), 1994, pp. 2511-2516
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
21
Year of publication
1994
Pages
2511 - 2516
Database
ISI
SICI code
0960-894X(1994)4:21<2511:PAOTFG>2.0.ZU;2-B
Abstract
An equation is described that relates the equilibrium distribution of compounds between blood and brain to various solute descriptors, for 5 7 varied compounds. It is shown that the main factors influencing the distribution are solute size that favours brain, and solute dipolarity / polarisability, hydrogen-bond acidity and hydrogen-bond basicity tha t favour blood. The descriptors can be obtained from measurements on c ompound substructures, so that the blood-brain distribution can be pre dicted for drug molecules without the necessity for synthesis.