SYNTHESIS OF ETOPOSIDE PHOSPHATE, BMY-40481 - A WATER-SOLUBLE CLINICALLY ACTIVE PRODRUG OF ETOPOSIDE

Authors
SAULNIER MG LANGLEY DR KADOW JF SENTER PD KNIPE JO TUN MM VYAS DM DOYLE TW
Citation
Mg. Saulnier et al., SYNTHESIS OF ETOPOSIDE PHOSPHATE, BMY-40481 - A WATER-SOLUBLE CLINICALLY ACTIVE PRODRUG OF ETOPOSIDE, Bioorganic & medicinal chemistry letters, 4(21), 1994, pp. 2567-2572
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
21
Year of publication
1994
Pages
2567 - 2572
Database
ISI
SICI code
0960-894X(1994)4:21<2567:SOEPB->2.0.ZU;2-M
Abstract
Etoposide Phosphate (BMY-40481) is synthesized semisynthetically from the clinically approved anticancer parent drug, etoposide (VP-16-213), and also from natural (-)-epipodophyllotoxin. Etoposide phosphate fun ctions as a clinically active, water soluble prodrug of etoposide. The NDA for etoposide phosphate was filed in June, 1994.