STEREOSELECTIVITY OF THE POSITIVE INOTROPIC EFFECTS OF NEWER DIAZINONE-CARDIOTONICS

Authors
JONAS R KLOCKOW M LUES I WURZIGER H
Citation
R. Jonas et al., STEREOSELECTIVITY OF THE POSITIVE INOTROPIC EFFECTS OF NEWER DIAZINONE-CARDIOTONICS, Bioorganic & medicinal chemistry letters, 4(21), 1994, pp. 2585-2588
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
21
Year of publication
1994
Pages
2585 - 2588
Database
ISI
SICI code
0960-894X(1994)4:21<2585:SOTPIE>2.0.ZU;2-P
Abstract
In 5-methyl-dihydropyridazinones, a stereoselectivity is observed only with respect to the phosphodiesterase III-inhibition. The (-)-enantio mers are very strong inhibitors whereas their (+)-counterparts exhibit only a weak activity. In the case of the thiadiazinone EMD 53998 a pr onounced stereoselectivity regarding Ca-sensitivity and phosphodiester ase inhibition is apparent. It is concluded that Levosimendan exerts i ts positive inotropism almost exclusively through its potent phosphodi esterase III-inhibitory effect.