EPSP SYNTHASE INHIBITOR DESIGN .4. NEW AROMATIC SUBSTRATE-ANALOGS ANDSYMMETRICAL INHIBITORS CONTAINING NOVEL 3-PHOSPHATE MIMICS

Authors
MILLER MJ BRACCOLINO DS CLEARY DG REAM JE WALKER MC SIKORSKI JA
Citation
Mj. Miller et al., EPSP SYNTHASE INHIBITOR DESIGN .4. NEW AROMATIC SUBSTRATE-ANALOGS ANDSYMMETRICAL INHIBITORS CONTAINING NOVEL 3-PHOSPHATE MIMICS, Bioorganic & medicinal chemistry letters, 4(21), 1994, pp. 2605-2608
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
21
Year of publication
1994
Pages
2605 - 2608
Database
ISI
SICI code
0960-894X(1994)4:21<2605:ESID.N>2.0.ZU;2-F
Abstract
New 4-deoxy aromatic analogs of S3P and EPSP have been synthesized as potential substrate-based inhibitors of EPSPS to evaluate various 3-ph osphate replacements in combination with the aromatic ring system. The se studies identified 3-malonate ethers and alpha-hydroxymethylphospho nates as suitable 3-phosphate mimics in this series and led to the dis covery of two unexpectedly potent symmetrical aromatic inhibitors 6 an d 7.