THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF TETRAHYDROQUINOLINE ANGIOTENSIN-II ANTAGONISTS CONTAINING A SUBSTITUTED BIPHENYLTETRAZOLE GROUP

Authors
THOMAS AP ROBERTS DA THOMASON DA
Citation
Ap. Thomas et al., THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF TETRAHYDROQUINOLINE ANGIOTENSIN-II ANTAGONISTS CONTAINING A SUBSTITUTED BIPHENYLTETRAZOLE GROUP, Bioorganic & medicinal chemistry letters, 4(21), 1994, pp. 2615-2620
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
21
Year of publication
1994
Pages
2615 - 2620
Database
ISI
SICI code
0960-894X(1994)4:21<2615:TSABOT>2.0.ZU;2-5
Abstract
The synthesis of analogues of tetrahydroquinoline angiotensin II antag onist, ZENECA ZD6888, bearing substituents on the biphenyl ring system is reported. Several of these compounds show comparable or superior a ctivity to ZD6888 in an in vitro binding assay and in inhibition of th e AII-induced presser response in normotensive rats.