SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A POTENT ANTIPLATELET 7-AMINOFUROCHROMONE

Authors
MORRIS J WISHKA DG HUMPHREY WR LIN AH WILTSE AL BENJAMIN CW GORMAN RR SHEBUSKI RJ
Citation
J. Morris et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A POTENT ANTIPLATELET 7-AMINOFUROCHROMONE, Bioorganic & medicinal chemistry letters, 4(21), 1994, pp. 2621-2626
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
21
Year of publication
1994
Pages
2621 - 2626
Database
ISI
SICI code
0960-894X(1994)4:21<2621:SABOAP>2.0.ZU;2-A
Abstract
The synthesis of a series of rigid analogs designed to explore the con formational requirements associated with the related 2-aminochromone 1 led to the identification of class of novel antiplatelet 7-aminofuroc hromes 2. A potent derivative 13 was further evaluated with regard to mechanism of action as well as in a canine model of platelet dependent thrombus formation.