After clinical recovery, 46 manic patients were screened for evidence
of life events during a period of 6 months before the first episode of
mania (DSMIIIR criteria) and 6 months after the episode. Within-patie
nt group comparisons showed that patients who reported life events had
a significantly higher presumptive mean stress score before manic epi
sode as compared with the period after the illness. When life events w
ere considered in relation to age, sex, marital status and family hist
ory of affective disorder, on a logistic regression equation, it was f
ound that life events before mania were significantly associated with
males; and with a younger age of onset. The implications of these find
ings are discussed.