5-METHYLTETRAHYDROFOLATE LEVEL IN THE SERUM OF DEPRESSED SUBJECTS ANDITS RELATIONSHIP TO THE OUTCOME OF ECT

Authors
WILKINSON AM ANDERSON DN ABOUSALEH MT WESSON M BLAIR JA FARRAR G LEEMING RJ
Citation
Am. Wilkinson et al., 5-METHYLTETRAHYDROFOLATE LEVEL IN THE SERUM OF DEPRESSED SUBJECTS ANDITS RELATIONSHIP TO THE OUTCOME OF ECT, Journal of affective disorders, 32(3), 1994, pp. 163-168
Citations number
29
Categorie Soggetti
Psychiatry,Psychiatry,"Clinical Neurology
Journal title
Journal of affective disorders → ACNP
ISSN journal
01650327
Volume
32
Issue
3
Year of publication
1994
Pages
163 - 168
Database
ISI
SICI code
0165-0327(1994)32:3<163:5LITSO>2.0.ZU;2-0
Abstract
Serum 5-MeTHF levels are reported in 26 subjects, before and after com pleting a course of ECT, and compared to 21 healthy volunteers. 5-MeTH F levels of depressed subjects were significantly lower than controls before and after ECT. There was no difference in 5-MeTHF levels betwee n ECT responders and non-responders but folate deficiency was related to severity of depression before ECT. Serum 5-MeTHF was not related to treatment response and values remained markedly low even after a good response to treatment.