G. Ulrich et al., ACUTE VS CHRONIC EEG EFFECTS IN MAPROTILINE-TREATED AND IN CLOMIPRAMINE-TREATED DEPRESSIVE INPATIENTS AND THE PREDICTION OF THERAPEUTIC OUTCOME, Journal of affective disorders, 32(3), 1994, pp. 213-217
Patients treated with the norepinephrine uptake inhibitor maprotiline
showed an opposite tendency between acute and chronic effect of EEG. W
hereas the acute effect indicated a decrease upon EEG vigilance, the c
hronic effect indicated an increase. Under clomipramine which acts upo
n different transmitter systems in a complex, up to now not fully unde
rstood way, acute and chronic EEG effects could not be differentiated.