Research is presented from three different cognitive aging laboratorie
s that examines the relationship between cognitive function, age, and
the ability to adhere to medication regimens. The first section focuse
s on the effectiveness of complete, explicit instructions that emphasi
ze the importance of organization of medication information on adheren
ce behaviors for both younger and older adults. The second section exa
mines the role of literal versus inferential medication information in
normal elderly and in Alzheimer's patients. This research demonstrate
s that traditional measures of cognitive functioning are correlated wi
th the comprehension of medication information and medication adherenc
e. Finally, the third section presents an overview of research issues
in adherence, including the relative effectiveness of two adherence me
asurements techniques, as well as a discussion of the effects of illne
ss beliefs on adherence and evidence that adherence is not a global be
havior but may vary within the individual as a function of certain med
ications. Directions for future research are suggested.