NEUROMUSCULAR AND CARDIOVASCULAR EFFECTS OF NEOSTIGMINE AND METHYL-ATROPINE ADMINISTERED AT DIFFERENT DEGREES OF ROCURONIUM-INDUCED NEUROMUSCULAR BLOCK
L. Vandenbroek et al., NEUROMUSCULAR AND CARDIOVASCULAR EFFECTS OF NEOSTIGMINE AND METHYL-ATROPINE ADMINISTERED AT DIFFERENT DEGREES OF ROCURONIUM-INDUCED NEUROMUSCULAR BLOCK, European journal of anaesthesiology, 11(6), 1994, pp. 481-487
The neuromuscular and cardiovascular effects of neostigmine, 40 mug kg
-1, and methyl-atropine, 7 mug kg-1, administered at different degrees
of rocuronium-induced (600 mug kg-1) neuromuscular block were evaluat
ed. In one group of patients spontaneous recovery was awaited (Group A
; n = 20). Neostigmine and methyl-atropine were administered 2 minutes
after rocuronium (Group B; n = 20) or at 25% twitch recovery (Group C
; n = 20). Neuromuscular transmission was monitored mechanomyographica
lly. Data are presented as mean (SD) [95%-Cl]. The initial rate of rec
overy (time until a TOF ratio of 0.2) in group B, i.e. 14.2 (4.5) [12.
1-16.3] min, was significantly faster than in group C, i.e. 28.7 (5.3)
[26.3-31.1] min. However, the time until clinically sufficient recove
ry (time until a TOF ratio of 0.7) was similar for groups B, i.e. 29.3
(9.5) [24.9-33.7] min and group C, i.e. 31.8 (5.6) [29.2-34.4] min, b
oth significantly different from that of group A, i.e. 53.2 (14.5) [46
.5-59.9] min. The increase in heart rate following neostigmine/methyl-
atropine was more pronounced in the group reversed at 2 min after rocu
ronium (P<0.01).