PROTEIN-KINASE-C MODULATORS - INDOLACTAMS .1. EFFICIENT AND FLEXIBLE ROUTES FOR THE PREPARATION OF (-)INDOLACTAM-V FOR USE IN THE SYNTHESISOF ANALOGS

Three syntheses of the protein kinase C activator, (-)-indolactam V, a re described and are compared for their potential utility in the prepa ration of ILV analogs. In one route the 4-amino functionality is intro duced regiospecifically during the construction of the indole portion and enantiomeric control is achieved by the alkylation of the amine wi th a triflate derived from D-valine. One of the routes affords racemic ILV from which (-)-ILV is obtained by the first reported resolution o f an indolactam.