CYCLOPOLYAMINES - SYNTHESIS OF CYCLOSPERMIDINES AND CYCLOSPERMINES, ANALOGS OF SPERMIDINE AND SPERMINE

Authors
BRAND G HOSSEINI MW RUPPERT R
Citation
G. Brand et al., CYCLOPOLYAMINES - SYNTHESIS OF CYCLOSPERMIDINES AND CYCLOSPERMINES, ANALOGS OF SPERMIDINE AND SPERMINE, Tetrahedron letters, 35(46), 1994, pp. 8609-8612
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
46
Year of publication
1994
Pages
8609 - 8612
Database
ISI
SICI code
0040-4039(1994)35:46<8609:C-SOCA>2.0.ZU;2-D
Abstract
The synthesis of a series of cyclic analogues of the naturally occurri ng polyamines putrescine, spermidine and spermine was achieved. The cy clic analogues of putrescine named cycloputrescine [4,n] were composed of cycloputrescine in which the two primary amines were connected wit h a polymethylene chain of variable length (n = 3, 4, 5). Cyclospermid ines [4,n] and Cyclospermines [4,n] were composed of a cycloputrescine [4,n] moiety mono- or difunctionalized with an aminopropyl chain resp ectively.