BETA-ANOMER SELECTIVITY IN 2'-DEOXYNUCLEOSIDE SYNTHESIS - A NOVEL-APPROACH USING AN ACYL CARBAMATE DIRECTING GROUP

Authors
YOUNG RJ SHAWPONTER S HARDY GW MILLS G
Citation
Rj. Young et al., BETA-ANOMER SELECTIVITY IN 2'-DEOXYNUCLEOSIDE SYNTHESIS - A NOVEL-APPROACH USING AN ACYL CARBAMATE DIRECTING GROUP, Tetrahedron letters, 35(46), 1994, pp. 8687-8690
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
46
Year of publication
1994
Pages
8687 - 8690
Database
ISI
SICI code
0040-4039(1994)35:46<8687:BSI2S->2.0.ZU;2-Z
Abstract
Glycosylation of silylated pyrimidines using a phenyl benzoyl)carbamoy l-1-thio-D-erythro-pentofuranoside yielded 2-deoxy-beta-ribonucleoside s in good yields with excellent anomeric selectivity. This prototype 3 -O-carbamate directing group was readily formed and removed in high yi elds.