ACYLATION OF LYCOCTONINE - SEMISYNTHESIS OF INULINE, DELSEMINE ANALOGS AND METHYLLYCACONITINE

Authors
BLAGBROUGH IS COATES PA HARDICK DJ LEWIS T ROWAN MG WONNACOTT S POTTER BVL
Citation
Is. Blagbrough et al., ACYLATION OF LYCOCTONINE - SEMISYNTHESIS OF INULINE, DELSEMINE ANALOGS AND METHYLLYCACONITINE, Tetrahedron letters, 35(46), 1994, pp. 8705-8708
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
46
Year of publication
1994
Pages
8705 - 8708
Database
ISI
SICI code
0040-4039(1994)35:46<8705:AOL-SO>2.0.ZU;2-4
Abstract
Lycoctonine has been acylated to afford sequentially inuline, delsemin e analogues and methyllycaconitine using isatoic anhydride followed by S-(-)-methylsuccinic anhydride. This protocol is a rapid, facile meth od for the regiospecific introduction of the anthranilate ester moiety found in potent nicotinic acetylcholine receptor antagonists.