SELECTIVE SYNTHESIS OF 4-AMINOBIPHENYL-N-2-DEOXYGUANOSINE ADDUCTS

Authors
SCHEER S STEINBRECHER T BOCHE G
Citation
S. Scheer et al., SELECTIVE SYNTHESIS OF 4-AMINOBIPHENYL-N-2-DEOXYGUANOSINE ADDUCTS, Environmental health perspectives, 102, 1994, pp. 151-152
Citations number
9
Categorie Soggetti
Public, Environmental & Occupation Heath","Environmental Sciences
Journal title
Environmental health perspectives → ACNP
ISSN journal
00916765
Volume
102
Year of publication
1994
Supplement
6
Pages
151 - 152
Database
ISI
SICI code
0091-6765(1994)102:<151:SSO4A>2.0.ZU;2-8
Abstract
A selective synthesis of N-2-deoxyguanosine adducts derived from 4-ami nobiphenyl (ABP) is described. The reactions of 3',5'-O-bis(tert-butyl dimethyl)-2'-deoxyxanthosine with 3-amino-4-aceiaminobiphenyl and 4-hy drazinobiphenyl, respectively, are the key steps. Successive removal o f the protecting groups from the protected adducts leads to the free a dducts 3-(deoxyguanosine-N-2-yl)-acetyl-ABP and N-(deoxyguanosyl-N-2-y l)-ABP, respectively.