MONOCLONAL IGM REACTIVE WITH SEVERAL GANGLIOSIDES IN A CHRONIC RELAPSING POLYNEUROPATHY

Authors
BRINDEL I PREUDHOMME JL VALLAT JM VINCENT D VASQUEZ JL JAUBERTEAU MO
Citation
I. Brindel et al., MONOCLONAL IGM REACTIVE WITH SEVERAL GANGLIOSIDES IN A CHRONIC RELAPSING POLYNEUROPATHY, Neuroscience letters, 181(1-2), 1994, pp. 103-106
Citations number
12
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
181
Issue
1-2
Year of publication
1994
Pages
103 - 106
Database
ISI
SICI code
0304-3940(1994)181:1-2<103:MIRWSG>2.0.ZU;2-B
Abstract
A possibly pathogenic serum monoclonal IgM lambda from a patient with chronic relapsing polyneuropathy was shown to react with the disialosy l-lactosyl residue (NeuAc alpha 2-8NeuAc alpha 2-3)-Gal beta 1-Glc exp ressed by GD1b, GT1b, GQ1b, GD2 and GD3. A part of this epitope in ter minal position in GM3, GD1a and LM1 was also recognized by the IgM lam bda.