OMEGA-AGA TOXIN-IVA BLOCKS HIGH-VOLTAGE-ACTIVATED CALCIUM-CHANNEL CURRENTS IN CULTURED PARS-INTERCEREBRALIS NEUROSECRETORY-CELLS OF ADULT LOCUSTA-MIGRATORIA

Authors
BICKMEYER U ROSSLER W WIEGAND H
Citation
U. Bickmeyer et al., OMEGA-AGA TOXIN-IVA BLOCKS HIGH-VOLTAGE-ACTIVATED CALCIUM-CHANNEL CURRENTS IN CULTURED PARS-INTERCEREBRALIS NEUROSECRETORY-CELLS OF ADULT LOCUSTA-MIGRATORIA, Neuroscience letters, 181(1-2), 1994, pp. 113-116
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
181
Issue
1-2
Year of publication
1994
Pages
113 - 116
Database
ISI
SICI code
0304-3940(1994)181:1-2<113:OTBHCC>2.0.ZU;2-P
Abstract
Using the whole cell patch-clamp technique, calcium (Ca) channel curre nts from cultured medial neurosecretory cells (MNSCs) of Locusta migra toria (Rossler and Bickmeyer, 1993) were investigated. The calcium cha nnel blocker omega AGA toxin IVA (AGA IVA) blocks a fraction of these calcium channel currents in similar to 30% of MNSCs, without a shift i n the I-V relationship. The block can be at least partially reversed b y strong depolarizing voltage pulses as described for vertebrate neuro nes from Mintz et al. (1992). The existence of probably more than thre e calcium channel types in insects is discussed.