INCREASED APOPTOSIS IN THE CINGULATE SULCUS OF NEWBORN PIGLETS FOLLOWING TRANSIENT HYPOXIA-ISCHEMIA IS RELATED TO THE DEGREE OF HIGH-ENERGYPHOSPHATE-DEPLETION DURING THE INSULT

Authors
MEHMET H YUE X SQUIER MV LOREK A CADY E PENRICE J SARRAF C WYLEZINSKA M KIRKBRIDE V COOPER C BROWN GC WYATT JS REYNOLDS EOR EDWARDS AD
Citation
H. Mehmet et al., INCREASED APOPTOSIS IN THE CINGULATE SULCUS OF NEWBORN PIGLETS FOLLOWING TRANSIENT HYPOXIA-ISCHEMIA IS RELATED TO THE DEGREE OF HIGH-ENERGYPHOSPHATE-DEPLETION DURING THE INSULT, Neuroscience letters, 181(1-2), 1994, pp. 121-125
Citations number
8
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
181
Issue
1-2
Year of publication
1994
Pages
121 - 125
Database
ISI
SICI code
0304-3940(1994)181:1-2<121:IAITCS>2.0.ZU;2-X
Abstract
An increase in the number of cells undergoing apoptosis was observed i n the cingulate sulcus of newborn piglets 48 h after a global hypoxic- ischaemic insult. Apoptotic death was identified morphologically (by l ight and electron microscopy) and by DNA fragmentation, detected by in situ end labelling. The number of apoptotic cells was directly relate d to the degree of high-energy phosphate depletion during hypoxia-isch aemia, measured using continuous P-31 magnetic resonance spectroscopy. These results may have implications for the understanding and treatme nt of perinatal hypoxic-ischaemic brain injury.