PHOSPHOLIPIDS METABOLISM IN PLATELETS STIMULATED WITH COLLAGEN

Authors
FERRI A CALZA R
Citation
A. Ferri et R. Calza, PHOSPHOLIPIDS METABOLISM IN PLATELETS STIMULATED WITH COLLAGEN, Biochemistry and molecular biology international, 34(4), 1994, pp. 693-698
Citations number
23
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
34
Issue
4
Year of publication
1994
Pages
693 - 698
Database
ISI
SICI code
1039-9712(1994)34:4<693:PMIPSW>2.0.ZU;2-T
Abstract
Collagen addition to platelets suspended in Calcium-free medium induce s slow shape change followed by fast aggregates formation. Time course s of membrane phospholipids metabolism and arachidonic acid oxidative metabolism indicate that phospholipase C is the immediate target of th e stimulus, and subsequently phospholipase A-2 is activated by synergi stic action of released calcium and protein kinase C.