HEPOXILINS - A REVIEW ON THEIR CELLULAR ACTIONS

This review is intended to summarize the biological actions of the hep oxilins reported to date. These actions appear to have, as their basis , changes in intracellular concentrations of ions including calcium an d potassium ions as well as changes in second messenger systems. Recen t evidence suggests that the biological actions of the hepoxilins may be receptor-mediated as indicated from data showing the existence of h epoxilin-specific binding proteins in the human neutrophil. Such evide nce also implicates the association of G-proteins both in hepoxilin-bi nding as well as in hepoxilin action. The potential use of stable anal ogs of the hepoxilins is discussed as well as the directions in which this area is heading.