Optimal migraine therapy begins with an accurate diagnosis and knowled
ge of the symptoms that the patient finds most disturbing. Pharmacolog
ic treatment of migraine may be acute (abortive, symptomatic) or preve
ntive (prophylactic); both approaches are frequently required in patie
nts with frequent, severe headaches. Drugs for acute care consist of a
nalgesics, antiemetics, anxiolytics, nonsteroidal anti-inflammatory dr
ugs, ergots, steroids, major tranquilizers, narcotics, and selective s
erotonin agonists. Preventive agents include beta-blockers, calcium ch
annel blockers, antidepressants, serotonin antagonists, and anticonvul
sants. The choice of a preventive drug depends on side effect profiles
and comorbid conditions. Behavioral interventions, such as biofeedbac
k and relaxation techniques, are an important complement to pharmacolo
gic therapy; however, drugs are the mainstay of migraine therapy. To e
nsure that therapy achieves optimal results, the individual patient's
preferred approach to this debilitating problem must be considered car
efully.