A NOVEL CYCLIN GENE (CCNF) IN THE REGION OF THE POLYCYSTIC KIDNEY-DISEASE GENE (PKD1)

The major locus for autosomal dominant polycystic kidney disease (PKD1 ) is located in a gene-rich region on chromosome 16p13.3. Recently the identification of the gene responsible for PKD1 has been described. W hile searching for candidate genes in this region, we isolated a new m ember of the cyclin family. We have characterized the transcript by se quencing, determination of the exon intron boundaries, and Northern bl ot analysis. Cyclin F is related to A- and B-type cyclins by sequence, but its function is unknown. (C) 1994 Academic Press, Inc.