COMPARISON OF 3 COMMERCIALLY AVAILABLE ASSAYS FOR DETECTION OF VARICELLA-ZOSTER VIRUS-ANTIBODY

Authors
MARTINS TB JASKOWSKI TD SCHRODER C STREETER B HILL HR
Citation
Tb. Martins et al., COMPARISON OF 3 COMMERCIALLY AVAILABLE ASSAYS FOR DETECTION OF VARICELLA-ZOSTER VIRUS-ANTIBODY, Clinical and diagnostic laboratory immunology, 1(2), 1994, pp. 186-188
Citations number
4
Categorie Soggetti
Immunology,"Infectious Diseases","Medical Laboratory Technology",Microbiology
Journal title
Clinical and diagnostic laboratory immunology → ACNP
ISSN journal
1071412X
Volume
1
Issue
2
Year of publication
1994
Pages
186 - 188
Database
ISI
SICI code
1071-412X(1994)1:2<186:CO3CAA>2.0.ZU;2-R
Abstract
Three commercially available diagnostic assays for the detection of an tibodies to varicella-zoster virus were evaluated to determine which w ould be the most suitable for our clinical laboratory. Three different methods were examined: an enzyme-linked immunosorbent assay (ELISA), latex agglutination (LA), and an indirect fluorescent-antibody techniq ue. For the 141 serum specimens tested, the ELISA had an agreement of 90.1% and LA had an agreement of 92.2% with the indirect immunofluores cent-antibody technique. The ELISA had a lower sensitivity (85.6%) tha n LA (100.0%), but LA suffered from a low specificity (78.4%) compared with the ELISA (98.0%).