DEVELOPMENT OF A MICROSATELLITE GENETIC-MAP SPANNING 5Q31-Q33 AND SUBSEQUENT PLACEMENT OF THE LGMD1A LOCUS BETWEEN D5S178 AND IL9

Authors
YAMAOKA LH WESTBROOK CA SPEER MC GILCHRIST JM JABS EW SCHWEINS EG STAJICH JM GASKELL PC ROSES AD PERICAKVANCE MA
Citation
Lh. Yamaoka et al., DEVELOPMENT OF A MICROSATELLITE GENETIC-MAP SPANNING 5Q31-Q33 AND SUBSEQUENT PLACEMENT OF THE LGMD1A LOCUS BETWEEN D5S178 AND IL9, Neuromuscular disorders, 4(5-6), 1994, pp. 471-475
Citations number
20
Categorie Soggetti
Neurosciences,"Clinical Neurology
Journal title
Neuromuscular disorders → ACNP
ISSN journal
09608966
Volume
4
Issue
5-6
Year of publication
1994
Pages
471 - 475
Database
ISI
SICI code
0960-8966(1994)4:5-6<471:DOAMGS>2.0.ZU;2-9
Abstract
Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linka ge analysis in a single large pedigree. After developing a microsatell ite genetic map incorporating six loci in q31-33 of chromosome 5 and s panning 35 cM, we have refined the original localization. Using multip oint analysis, LGMD1A is localised to a 7 cM region between the marker s IL9 and D5S178 with odds > 1000:1.