TRANSFORMING GROWTH-FACTOR-BETA IN ALZHEIMERS-DISEASE

Authors
CHAO CC HU SX FREY WH ALA TA TOURTELLOTTE WW PETERSON PK
Citation
Cc. Chao et al., TRANSFORMING GROWTH-FACTOR-BETA IN ALZHEIMERS-DISEASE, Clinical and diagnostic laboratory immunology, 1(1), 1994, pp. 109-110
Citations number
14
Categorie Soggetti
Immunology,"Infectious Diseases","Medical Laboratory Technology",Microbiology
Journal title
Clinical and diagnostic laboratory immunology → ACNP
ISSN journal
1071412X
Volume
1
Issue
1
Year of publication
1994
Pages
109 - 110
Database
ISI
SICI code
1071-412X(1994)1:1<109:TGIA>2.0.ZU;2-D
Abstract
Alzheimer's disease (AD) has been hypothesized to be an inflammatory c ondition. We hypothesized that anti-inflammatory cytokines, such as tr ansforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elev ated in both cerebrospinal fluid and serum samples obtained from AD pa tients <6 h after death. Serum TGF-beta levels were also markedly elev ated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically med iated neuronal injury.