LEVELS OF CIRCULATING FIBRONECTIN RECEPTOR IN ADULT AND PEDIATRIC-PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION

Authors
TORRE D ZEROLI C PUGLIESE A GIOLA M FERRARIO G BONETTA G ISSI M MARTEGANI R SPERANZA F FIORI GP
Citation
D. Torre et al., LEVELS OF CIRCULATING FIBRONECTIN RECEPTOR IN ADULT AND PEDIATRIC-PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION, Clinical and diagnostic laboratory immunology, 1(3), 1994, pp. 348-350
Citations number
15
Categorie Soggetti
Immunology,"Infectious Diseases","Medical Laboratory Technology",Microbiology
Journal title
Clinical and diagnostic laboratory immunology → ACNP
ISSN journal
1071412X
Volume
1
Issue
3
Year of publication
1994
Pages
348 - 350
Database
ISI
SICI code
1071-412X(1994)1:3<348:LOCFRI>2.0.ZU;2-3
Abstract
We found a significant increase in fibronectin receptor (FNR) levels i n the sera of adult human immunodeficiency virus type 1 (HIV-1)-infect ed patients, especially in those with AIDS (1,026.9 +/- 583.9 ng/ml; P < 0.0001). In contrast, AIDS patients with neurologic disorders and H IV-1-seropositive patients showed normal levels of FNR in serum. In ad dition, HIV-1-infected children showed increased levels of FNR in seru m (824.4 +/- 333.5 ng/ml; P = 0.03). We suggest that an increase of FN R levels in AIDS patients is related to enhanced expression of FNR on HIV-1-infected cells.