CHARACTERIZATION OF AN ANTIGENIC OLIGOSACCHARIDE FROM LEPTOSPIRA-INTERROGANS SEROVAR POMONA AND ITS ROLE IN IMMUNITY

Authors
MIDWINTER A VINH T FAINE S ADLER B
Citation
A. Midwinter et al., CHARACTERIZATION OF AN ANTIGENIC OLIGOSACCHARIDE FROM LEPTOSPIRA-INTERROGANS SEROVAR POMONA AND ITS ROLE IN IMMUNITY, Infection and immunity, 62(12), 1994, pp. 5477-5482
Citations number
32
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
12
Year of publication
1994
Pages
5477 - 5482
Database
ISI
SICI code
0019-9567(1994)62:12<5477:COAAOF>2.0.ZU;2-W
Abstract
An antigenic oligosaccharide fraction derived from the lipopolysacchar ide of Leptospira interrogans serovar pomona nas isolated by endo-glyc osidase H digestion and column chromatography. The oligosaccharide con tained rhamnose, ribose, glucose, and glucosamine and inhibited the bi nding of opsonic, protective monoclonal antibodies directed against th e lipopolysaccharide. When conjugated to diphtheria toroid, the oligos accharide elicited the production of agglutinating, opsonic antibodies .