ANTIBODY-RESPONSE TO A BABESIA-BIGEMINA RHOPTRY-ASSOCIATED PROTEIN-1 SURFACE-EXPOSED AND NEUTRALIZATION-SENSITIVE EPITOPE IN IMMUNE CATTLE

Authors
USHE TC PALMER GH SOTOMAYOR L FIGUEROA JV BUENING GM PERRYMAN LE MCELWAIN TF
Citation
Tc. Ushe et al., ANTIBODY-RESPONSE TO A BABESIA-BIGEMINA RHOPTRY-ASSOCIATED PROTEIN-1 SURFACE-EXPOSED AND NEUTRALIZATION-SENSITIVE EPITOPE IN IMMUNE CATTLE, Infection and immunity, 62(12), 1994, pp. 5698-5701
Citations number
13
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
12
Year of publication
1994
Pages
5698 - 5701
Database
ISI
SICI code
0019-9567(1994)62:12<5698:ATABRP>2.0.ZU;2-B
Abstract
Protective immunity against Babesia bigemina is hypothesized to involv e antibodies directed against merozoite surface-exposed epitopes. Leve ls of antibody against a rhoptry-associated protein 1 (RAP-1) B-lympho cyte epitope, defined by surface-reactive and inhibitory monoclonal an tibodies, in immune cattle sera were determined. Ail cattle produced a ntibodies to the epitope; however, there was limited correlation betwe en immune protection induced by infection or RAP-1 immunization and th e level of antibody to the neutralization-sensitive B-lymphocyte epito pe examined.