NAFARELIN THERAPY IN ENDOMETRIOSIS - LONG-TERM EFFECTS ON BONE-MINERAL DENSITY

OBJECTIVE: The study intent was to examine long-term effects on bone m ass of 3 or 6 months of nafarelin therapy for endometriosis. STUDY DES IGN: Women with established endometriosis (N = 173) were randomized to receive nafarelin (200 mu g intranasally twice a day) for either 3 or 6 months in a double-blind fashion. Bone mineral density was measured by dual energy x-ray absorptiometry at lumbar spine and proximal femo ral sites for 18 months. RESULTS: Bone mineral density declined at spi nal and femoral sites similarly in both 3- and 6-month treatment group s. There was a partial, but incomplete, return to,baseline levels afte r 12 to 15 months of follow-up. The recovery of bone mass was more com plete in subjects with higher dietary calcium intakes. CONCLUSION: Naf arelin therapy for endometriosis results in a sustained loss of spinal and femoral bone density, particularly in women with lower calcium in takes.