A SHORT SYNTHESIS OF VICINE AND CONVICINE, THE CAUSATIVE AGENTS OF FAVISM

Authors
KUNESCH N MIET C POISSON J
Citation
N. Kunesch et al., A SHORT SYNTHESIS OF VICINE AND CONVICINE, THE CAUSATIVE AGENTS OF FAVISM, Liebigs Annalen der Chemie, (11), 1994, pp. 1059-1063
Citations number
41
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen der Chemie → ACNP
ISSN journal
01702041
Issue
11
Year of publication
1994
Pages
1059 - 1063
Database
ISI
SICI code
0170-2041(1994):11<1059:ASSOVA>2.0.ZU;2-W
Abstract
Vicine (1) and convicine (2) (Vicia faba), causative of the human dise ase favism, have been conveniently prepared in good yields by a three- step synthesis starting from ethyl glyoxylate. The key step is the rea ction of a suitable tetra-O-acetylglucopyranoside with a large excess of guanidine with causes simultaneously deacetylation and coupling.