C. Herdeis et al., SYNTHESIS OF (2R,5R)-5-CHLOROPIPECOLIC ACID VIA A HOMOCHIRAL ACYLIMINIUM ION INTERMEDIATE, Liebigs Annalen der Chemie, (11), 1994, pp. 1117-1120
An efficient synthesis of (2R,5R)-5-chloropipecolic acid hydrochloride
(11) is described, starting from the readily available methyl tyldime
thylsilyloxy)-2-oxopiperidine-1-carboxylate (3).