SH2 AND SH3 DOMAINS AS MOLECULAR ADHESIVES - THE INTERACTIONS OF CRK AND ABL

Authors
FELLER SM REN RB HANAFUSA H BALTIMORE D
Citation
Sm. Feller et al., SH2 AND SH3 DOMAINS AS MOLECULAR ADHESIVES - THE INTERACTIONS OF CRK AND ABL, Trends in biochemical sciences, 19(11), 1994, pp. 453-458
Citations number
38
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
19
Issue
11
Year of publication
1994
Pages
453 - 458
Database
ISI
SICI code
0968-0004(1994)19:11<453:SASDAM>2.0.ZU;2-G
Abstract
The Src homology domains SH2 and SH3 are modular components present in many signal transduction proteins. They allow rapid formation of stab le protein complexes and may also regulate protein function through in tramolecular binding events. SH2 domains recognize phosphotyrosyl resi dues in a specific sequence context, while SH3 domains recognize a Pxx P motif and additional residues that mediate binding specificity.