HISTIDINE AND ASPARTATE PHOSPHORYLATION - 2-COMPONENT SYSTEMS AND THELIMITS OF HOMOLOG

Authors
SWANSON RV ALEX LA SIMON MI
Citation
Rv. Swanson et al., HISTIDINE AND ASPARTATE PHOSPHORYLATION - 2-COMPONENT SYSTEMS AND THELIMITS OF HOMOLOG, Trends in biochemical sciences, 19(11), 1994, pp. 485-490
Citations number
41
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
19
Issue
11
Year of publication
1994
Pages
485 - 490
Database
ISI
SICI code
0968-0004(1994)19:11<485:HAAP-2>2.0.ZU;2-W
Abstract
Autophosphorylating histidine kinase and response-regulator domains co nstitute the building blocks of two-component signaling systems. These systems use a unique phosphotransfer chemistry to regulate many aspec ts of bacterial physiology. Homologous systems are now being found in eukaryotes. Despite their common mechanism of phosphotransfer, the two -component systems display an extensive diversity in the arrangement o f their domains, and flexibility in their roles in different signal tr ansduction circuits.