INCIDENCE OF SEROCONVERSION FOR HEPATITIS-C VIRUS IN CHRONIC-HEMODIALYSIS PATIENTS - A PROSPECTIVE-STUDY

We conducted a prospective study in HD patients of our unit to evaluat e the incidence of seroconversion for HCV in this high-risk group. Two hundred and thirty-five patients were observed during the average fol low-up of 29.4 months: 183 were seronegative and 52 seropositive for a nti-HCV antibodies at the start of the study. During the observation p eriod two of 183 patients developed anti-HCV antibodies late in the st udy, while the other 181 patients remained seronegative throughout the observation period; anti-HCV antibodies persisted through the follow- up in the 52 HCV-positive patients at the beginning of the study. Our results showed a very low incidence of HCV seropositivity (0.44% per y ear) after implementation of our operative protocol including 'univers al precautions' and other infection control procedures. Once infected, there is no disappearance rate of anti-HCV. The 4-RIBA results did no t change during the follow-up period. Prevalence of HCV RNA by PCR tec hnique was 41% (22 of 54) among anti-HCV-positive patients. Future inv estigations are warranted to clarify the exact route of transmission o f HCV among HD patients and to reduce the rate of HCV transmission in this clinical setting.