R. Cammack et al., EPR SPECTROSCOPIC STUDIES OF HEMOGLOBIN BREAKDOWN IN MALARIAL PARASITE-INFECTED ERYTHROCYTES, Journal of the Chemical Society. Faraday transactions, 90(22), 1994, pp. 3409-3410
Citations number
12
Categorie Soggetti
Chemistry Physical","Physics, Atomic, Molecular & Chemical
EPR spectra of an insoluble fraction from the rodent malarial parasite
Plasmodium berghei, grown in mouse erythrocytes, have been measured.
Signals due to high-spin iron(III) haem and two low-spin haem species
were detected. Comparison with other derivatives of haemoglobin, and t
he use of a simple ligand-field model, identified the low-spin species
as imidazole-hydroxy and bis-imidazole derivatives of haem. These spe
cies may represent intermediate stages in the breakdown of haemoglobin
to the insoluble form, haemozoin. The utility of EPR spectroscopy for
the study of the breakdown pathway is discussed.